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KMID : 0381920060360020101
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Korean Journal of Microscopy
2006 Volume.36 No. 2 p.101 ~ p.108
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Expression of Myelin-Associated Glycoprotein (MAG) in the Aged Rat Cerebrum
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Cho Ik-Hyun
Park Chang-Hyun
Lee Jong-Hwan
Bae Chun-Sik
Ye Sang-Gyu
Lee Beob-Yi
Park Seung-Hwa
Koh Ki-Seok
Kim Jin-Seok
Chang Byung-Joon
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Abstract
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Myelin-associated glycoprotein (MAG) has been known to have a crucial role to the formation of myelin sheath during initial stage of myelination. In the present study, we investigated the aging-related expressional changes of MAG in the rat cerebrum. MAG expression was markedly decreased in cerebral cortex by aging. In the adult rat cerebrum, MAG-positive cells were process-bearing cells with large nucleus, and extensively distributed. However, in the aged rat brain, MAG-positive cells showed small and round morphology with little cytoplasm and few processes. MAG was co-expressed with galatocerebroside, but not with Iba-1, or GFAP. These results suggest that the expressional change of MAG-positive cells is associated with degeneration of oligodendrocyte-myelin system by aging, and that MAG is likely to be a reliable marker for the mature oligodendrocytes in the aged rat brain.
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KEYWORD
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Aging, Myelin-associated glycoprotein (MAG), Oligodendrocyte
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